RESUMO
New York City is currently experiencing an outbreak of COVID-19, a highly contagious and potentially deadly virus, which is particularly dangerous for older adults. This pandemic has led to public health policies including social distancing and stay-at-home orders. We explore here the impact of this unique crisis on victims of elder mistreatment and people at risk of victimization. The COVID-19 outbreak has also had a profound impact on the organizations from many sectors that typically respond to protect and serve victims of elder mistreatment. We examine this impact and describe creative solutions developed by these organizations and initial lessons learned in New York City to help inform other communities facing this pandemic and provide guidance for future crises.
Assuntos
Infecções por Coronavirus , Vítimas de Crime/psicologia , Serviços de Saúde para Idosos , Pandemias , Pneumonia Viral , Política Pública , Isolamento Social/psicologia , Idoso , Betacoronavirus/isolamento & purificação , Betacoronavirus/patogenicidade , COVID-19 , Doença Crônica/epidemiologia , Controle de Doenças Transmissíveis/métodos , Infecções por Coronavirus/diagnóstico , Infecções por Coronavirus/mortalidade , Infecções por Coronavirus/fisiopatologia , Infecções por Coronavirus/psicologia , Abuso de Idosos/economia , Abuso de Idosos/legislação & jurisprudência , Abuso de Idosos/prevenção & controle , Abuso de Idosos/psicologia , Feminino , Serviços de Saúde para Idosos/normas , Serviços de Saúde para Idosos/tendências , Humanos , Masculino , Mortalidade , Cidade de Nova Iorque/epidemiologia , Pneumonia Viral/diagnóstico , Pneumonia Viral/mortalidade , Pneumonia Viral/fisiopatologia , Pneumonia Viral/psicologia , Política Pública/legislação & jurisprudência , Política Pública/tendências , Medição de Risco , SARS-CoV-2RESUMO
A bioinspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-responsive DNase I nanocapsule (NCa) was developed for targeted cancer treatment. The NCl was assembled from a long-chain single-stranded DNA synthesized by rolling-circle amplification (RCA). Multiple GC-pair sequences were integrated into the NCl for enhanced loading capacity of the anticancer drug doxorubicin (DOX). Meanwhile, negatively charged DNase I was encapsulated in a positively charged acid-degradable polymeric nanogel to facilitate decoration of DNase I into the NCl by electrostatic interactions. In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy.
